- Basic science
- Species in use
- Mechanism of action
- Clinical practice
- Indication
- Contraindication
- Side effects
- Options for dressing
- Clinical application
(net boot) - Clinical application
(cage dressing) - Clinical application
(biobag) - Clinical cases
- Cases Part1
- Cases Part2
- Treatment result
- Products
- Products lineup
- Production facilities
- References
- ～2012
- ～2000
- ～1985
- Contact address
- Species in use
- Greenbottle fly (Lucilia sericata)
We use maggots of greenbottle flies (Lucilia sericata). This is one of the most commonly used species for medical purposes throughout the world.
- Mechanism of action
- Step 1: Wound debridement
- Maggots selectively liquefy necrotic tissue by secreting/excreting proteolytic enzymes, then ingest it by suction.
- Step 2: Antimicrobial activities
- Maggot secretions/excretions contain antimicrobial peptides, which are effective against certain kinds of pathogenic bacteria, including some kinds of anti-drug bacteria. They are also reported to degrade biofilms of Staphylococcus aureus and Pseudomonas aeruginosa.
- Step 3: Promotion of wound healing
- Recent studies show that certain agents in maggot secretions/excretions also promote regrowth of healthy granulation tissue by accelerating angiogenic activity and/or fibroblast migration.
