Biotherapy Medical and Maggot Debridement Therapy
Biotherapy Medical, Shiga
Species in use 
Greenbottle fly
Greenbottle fly (Lucilia sericata)

We use maggots of greenbottle flies (Lucilia sericata). This is one of the most commonly used species for medical purposes throughout the world.

Mechanism of action 
Step 1: Wound debridement
Maggots selectively liquefy necrotic tissue by secreting/excreting proteolytic enzymes, then ingest it by suction.
Step 2: Antimicrobial activities
Maggot secretions/excretions contain antimicrobial peptides, which are effective against certain kinds of pathogenic bacteria, including some kinds of anti-drug bacteria. They are also reported to degrade biofilms of Staphylococcus aureus and Pseudomonas aeruginosa.
Step 3: Promotion of wound healing
Recent studies show that certain agents in maggot secretions/excretions also promote regrowth of healthy granulation tissue by accelerating angiogenic activity and/or fibroblast migration.